Delivery System


AKVANO® is a novel proprietary drug delivery system. It represents an innovative dosage form consisting of water-free, sprayable liquid formulations in which selected lipids and the active ingredient are dissolved in a volatile solvent.

  • AKVANO® technology is based on water-free lipid formulations.
  • Selected lipids and optional active ingredient are dissolved in a volatile solvent.
  • Different lipid combinations provide desired properties in order to optimize the incorporation and function of active components in the formulation.
  • After quick drying, a thin lipid layer is formed on the skin surface for effective deposition of the active ingredient.
  • The formulation is a sprayable liquid, suitable for topical administration.
  • AKVANO® is also suitable for other delivery options like for example: drops, solution, stick, medical wipes and more

Read more: “Introduction to Lipids”>


Delivery System Benefits

Several studies show that AKVANO® delivery system has several advantages and benefits when compared with classical cream and ointments and other topical formulations on the market. The direct deposition of lipids and active compounds leads to highly efficient physicochemical interaction with the skin barrier, resulting in quicker, direct penetration into the stratum corneum and potentially a faster onset of action of active compounds. This is ideal for reformulation of older active substances, but also in finding the optimal formulation for a New Chemical Entity.

Clinical benefits

  • Improved Efficacy
    Higher efficacy of the drug can lead to a reduced dosage and/or shortened treatment period.
  • Improved Safety
    Improved efficacy can lead to improved safety including less side effects.
  • Tunable release profile
    By varying the AKVANO® composition it is possible to fine-tune the delivery speed from slow to fast.
  • Antiseptic
    Inherent antiseptic characteristics, without any added antimicrobial substances.
  • Reduced risk of infection
    More convenient to apply/administer to infected wounds avoiding potential infections or pain during application.
  • Prevents skin dehydration
    Lipid layer provides intrinsic moisturizing, emollient and soothing effects. Implies less need for additional creams/emollients.
  • Defined dosage
    When spraying is employed, the device ensures a very accurate dosing and an evenly distributed lipid layer.

Patient benefits

  • Excellent cosmetic qualities and convenience
    Excellent cosmetic qualities and greater convenience for patients mean AKVANO® formulations (particularly as a spray) are likely to be preferred by patients ahead of ointments and creams.
    – Quick and simple to use.
    – Dries very quickly.
    – Has a pleasant feeling on the skin.
    – Non-greasy and non-sticky.
    – Can be worn comfortably under clothes without staining them.
    – Invisible once dry.
    – Allows non-touch application for sensitive skin.
  • Reduced irritation
    AKVANO® formulations do not require preservatives or additional components that may cause skin irritation. Furthermore, AKVANO® formulations reinforce the skin barrier function which render the skin less susceptible for irritation. Non-touch application also minimizes irritation for sensitive skin.
  • Increased patient compliance
    The preferred properties of AKVANO® mean it has the potential to increase compliance rates – leading to better efficacy outcomes, and increasing the willingness of physicians to prescribe the treatment to new patients.

AKVANO® vs Ointments and Creams

As a delivery method for topical treatment, AKVANO® technology is fundamentally different from today’s traditional ointments and creams – the two most often used dosage forms containing lipids or lipid-like components.

In ointments and creams, the lipid components are stabilized in a hydrophobic base (ointments) or as lipid-water aggregates or particles (creams), which in both cases complicate interaction with the skin surface.

In both cases the initial thick layer needs to be rubbed into the skin before the lipids start to become released from the original ointment/cream system.

AKVANO® formulations consist of lipid components which are dissolved in a volatile, water-free solvent mixture. When this formulation is applied onto the skin, the solvent evaporates and a lipid layer is formed in an immediate interaction with the skin surface. This direct deposition of lipids makes the AKVANO® principle fundamentally different from other dosage forms.


Delivery System Components

AKVANO® formulations consist of components that are well-known in dermatology
applications and are also natural and free from preservatives and irritants:

  • Phospholipids are natural materials of vegetable origin; they soften the skin, strengthens the skin barrier and alleviates irritation.
  • Other lipids can be used to to control the penetration into the skin.
  • Keratolytic agents (optional), such as urea, lactic acid and others, soften the skin and have a water binding ability.
  • Alcohol solvent systems, mainly ethanol, are powerful antiseptics.
  • Other solvents or excipients such as silicone oils, denaturing agents, fragrances and thickeners can be used.

Feasibility Study

The first step in a cooperation can be a Feasibility Study consisting of:

  1. NDA and Feasibility Study Agreement agreed.
  2. Lipidor receives compounds and investigates different AKVANO®/compound formulations.
  3. Stability indicating methods are developed.
  4. Prototype candidate formulations intended for preclinical and/or clinical trials are selected, followed by indicative accelerated stability tests.
  5. Optionally, the prototype formulations are subjected to in vitro penetration studies (diffusion cell experiments).
  6. Final prototype candidate(s) are selected  for evaluation.

The cooperation can already from start take a longer-term perspective and be defined in a licensing agreement.

Intellectual Property

Lipidor holds a broad IPR position relating to AKVANO® in pharma, consumer health care and animal care.  Presently, ten patents have been granted, e.g in USA, Japan and China. Several patent applications are pending in totally 15 territories. The portfolio consists of four patent families and include various aspects of the lipid layer forming composition, use for treatment of psoriasis and other indications and a vast number of compositions with active ingredients.