AKVANO® is a novel proprietary drug delivery system. It represents an innovative dosage form consisting of water-free, sprayable liquid formulations in which selected lipids and the active ingredient are dissolved in a volatile solvent.
Using the flexibility of the AKVANO® platform means generic medicine can be transformed and reformulated into new, innovative treatments. Treatments that are quick and simple to use, reduce irritation and display excellent cosmetic qualities.
How it works
AKVANO® is a new formulation platform for topical delivery of various active ingredient at the desired target site, while minimizing local irritation and providing a convenient mode of application.
The AKVANO® technology is based on water-free lipid formulations. Preferred lipids and elective active ingredients are dissolved in a volatile solvent system. Different lipid combinations provide desired properties in order to optimize the incorporation and function of active components in the formulation.
After quick drying, a thin lipid layer is formed on the skin surface which enables an effective deposition of the active ingredient.
The formulation is normally a sprayable liquid, suitable for topical administration. However, AKVANO® is also suitable for a number of other delivery options like drops, solution, stick, medical wipes and more.
Features
The AKVANO® delivery system has several advantages and benefits when compared with classical cream and ointments. The direct deposition of lipids and active compounds leads to highly efficient interaction with the skin barrier.
By varying the AKVANO® composition it is possible to fine-tune the delivery speed from slow to fast. Furthermore, when spraying is employed, the device ensures a highly accurate dosing and an evenly distributed lipid layer.
AKVANO® incorporates inherent antiseptic characteristics, without added antimicrobial substances which will minimize the risk of bacterial resistance development. It has non-touch application on infected wounds, avoiding the risk of potential cross infections.
Higher drug efficacy with AKVANO® results in a reduced dosage and/or shortened treatment period which further enhance the safety along with less side effects. Also, the Lipid bilayer provides intrinsic moisturizing, emollient and soothing effects without any need for additional skin hydrating substances.
AKVANO® formulations consist of components that are well-known in dermatology applications and are also natural and free from preservatives and irritants.
AKVANO® is fundamentally different from ointments and creams. In ointments and creams, active components need to pass through one or several phase boundaries, and rubbing is needed for the formulation to interact with the skin. In contrast, AKVANO® formulations forms an even lipid layer on the skin surface after the solvent quickly evaporates and thereby facilitates an efficient interaction with the skin where no rubbing is required.
Ointments form an occlusive layer on the skin from which the active substance slowly diffuses into the stratum corneum.
Creams consist of small droplets from which the active substance has to pass phase boundaries in order to reach the stratum corneum.
AKVANO® instantly forms a thin lipid layer in which the active substance is evenly distributed enabling quicker, direct penetration into the stratum corneum.
Lipidor holds a broad IPR position relating to AKVANO® in pharma, consumer health care and animal care. Presently, our patents cover USA, Canada, Japan, Europe, China and several other territories. Additional patent applications are in process. The portfolio consists of five patent families and includes various aspects of the lipid layer forming composition, use for treatment of psoriasis and other skin conditions and a vast number of compositions with active ingredients.
Learn more about the science and technology behind the AKVANO® delivery system by accessing to the selected publications below.